Project 11

Catalytic carboxylation techniques with isotopically labelled CO2 (WP4)

Host institution: ICIQ, Spain
Deadline for application: 1st April 2020
3 PhD year position. Expected start date: Mid 2020.
Remember to read the eligibility criteria here.

Objectives:

  1. Optimize reaction conditions for systems developed in WP1 for catalytic carboxylation of alkyl halides with 13CO2
  2. Optimize reaction conditions for catalytic carboxylation of (un)saturated hydrocarbons with 13CO2
  3. Implementation of radiolabelling carboxylation techniques with 11CO2 and 14CO2
  4. Study the late-stage catalytic radiolabelling carboxylations with preselected pharmaceutical precursors

Expected Results:

  1. A catalytic system that allows for incorporating isotopically labelled 11CO2 , 13CO2 and 14CO2 into organic molecules
  2. A unique tool to understand the absorption, distribution, metabolism and excretion studies (ADME) of pharmaceutical candidates by radiolabelling with 11CO2 or 14CO2

Planned secondment(s):

  • Industrial secondment to AZ to Dr. Elmore (3 months): Work on industrial 14CO2 labelling (with ESR12).
  • AU to Prof. Skrydstrup (2 months): Work with two-chamber systems for the utilization of CO2 in carboxylation technologies and 11C-PET labelling (with ESR9).
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Enrolment in Doctoral degree: ESR11 will have the daily work at ICIQ, but will be formally enrolled at URV, Spain

Principal Supervisor: Prof. Ruben Martin (ICIQ)

Questions? Write to us at co2perate@uit.no.