Project 11

Catalytic carboxylation techniques with isotopically labelled CO₂ (WP4)

Host institution: ICIQ, Spain
Deadline for application: 1st April 2020
3 PhD year position. Expected start date: Mid 2020.
Remember to read the eligibility criteria here.

Objectives:

1. Optimize reaction conditions for systems developed in WP1 for catalytic carboxylation of alkyl halides with ¹³CO₂
2. Optimize reaction conditions for catalytic carboxylation of (un)saturated hydrocarbons with ¹³CO₂
3. Implementation of radiolabelling carboxylation techniques with ¹¹CO₂ and ¹⁴CO₂
4. Study the late-stage catalytic radiolabelling carboxylations with preselected pharmaceutical precursors

Expected Results:

1. A catalytic system that allows for incorporating isotopically labelled ¹¹CO₂ , ¹³CO₂ and ¹⁴CO₂ into organic molecules
2. A unique tool to understand the absorption, distribution, metabolism and excretion studies (ADME) of pharmaceutical candidates by radiolabelling with ¹¹CO₂ or ¹⁴CO₂

Planned secondment(s):

• Industrial secondment to AZ to Dr. Elmore (3 months): Work on industrial ¹⁴CO₂ labelling (with ESR12).
• AU to Prof. Skrydstrup (2 months): Work with two-chamber systems for the utilization of CO₂ in carboxylation technologies and ¹¹C-PET labelling (with ESR9).

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Enrolment in Doctoral degree: ESR11 will have the daily work at ICIQ, but will be formally enrolled at URV, Spain

Principal Supervisor: Prof. Ruben Martin (ICIQ)

Questions? Write to us at co2perate@uit.no.