Project 6

Efficient synthesis of fluorine-containing oxazolidinones from atmospheric CO₂ (WP2)

Host institution: University of Zurich (UZH), Switzerland
Application Deadline: 31st May 2020
3 PhD year position. Expected start date: Mid 2020.
Remember to read the eligibility criteria here.

Objectives:

1. Develop catalytic processes for the efficient synthesis of fluorinated oxazolidinones from propargylamines, electrophilic fluorinating agents and atmospheric CO₂ with special focus on non-precious metals.
2. Acquire in depth mechanistic understanding on this transformation
3. Design chiral Lewis acid catalysts for asymmetric reactions
   

Expected results:

1. Reliable catalytic system for the synthesis of highly functionalized fluorinated oxazolidinones
2. Kinetic profiles supported by DFT calculations unravelling the steps along the catalytic cycle
3. Library of F-containing oxazolidinones with pharmaceutical potential

Planned secondments:

• AU to Prof. Skrydstrup (3 months): Development of a compartmentalized reaction set up (with ESR2).
  
• Industrial secondment to AZ, Dr. Johansson (3 months): Design of chiral catalyst for enantioselective CO₂ incorporation.

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Enrolment in Doctoral degree(s): University of Zurich, Switzerland

Principal Supervisor: Prof. Cristina Nevado (UZH)